![]() Pope, who has published more than 455 peer-reviewed articles, 15 chapters, 500 abstracts and several Cochrane meta-analysis reviews, says that at first, patients who hadn’t been on HCQ clamored for prescriptions and those who had been on it in the past wanted it restarted. Janet Pope, a professor of medicine in the Division of Rheumatology at Western University in London who commonly prescribes HCQ, saw her patients’ attitudes toward the drug evolve during the pandemic. The study began in April and aimed to recruit 3,000 front-line workers but was able to recruit only 624 participants after waning evidence and enthusiasm for the drug became public. More recently, Detroit’s Henry Ford Health System quietly ended a study on the prophylactic benefits of HCQ as protection from COVID-19 for front-line workers. Food and Drug Administration (FDA) issued emergency-use authorization for HCQ in the treatment of COVID-19. Shortly after Trump’s false claims, the U.S. President Donald Trump made hydroxychloroquine a household word when he tweeted at the beginning of the pandemic that it had “a real chance to be one of the biggest game changers in the history of medicine.” He then added: “What do you have to lose? I’ll say it again: What do you have to lose? Take it.” Research presented at the American College of Rheumatology (ACR) annual meeting in November reiterated HCQ’s safety and restored its good reputation. Īlthough HCQ has not been proven as an effective treatment for COVID-19, it remains the cornerstone of therapy for autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Initially used to prevent and treat malaria and classified as an anti-malarial drug, the medication is better understood today, has multiple medical uses and is on the World Health Organization’s List of Essential Medicines. ![]() The active ingredient is quinine, derived from the bark of cinchona trees native to South America. Yet, HCQ is a remarkable medication with a fascinating history. Touted as a miracle cure for COVID-19 at the beginning of the pandemic, it finished the year plagued with concerns about adverse cardiac events. Hydroxychloroquine (HCQ) has had a rollercoaster ride of a year.
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